Our Services

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Translational Research Solutions

We are conducting translational research as part of the global biomarker/companion diagnostics (BM/CDx) function of the Daiichi Sankyo Group. By integrated analysis of pre-clinical and clinical samples using cutting-edge technologies, we provide the information needed for drug development, such as a drug’s mechanism of action (determining how a drug works); efficacy or target-engagement biomarker development (finding ways to detect a drug’s efficacy); predictive biomarker discovery (determining which patient groups a drug works in); indication selection (working out which indications are appropriate for a drug); and combination selection (finding out which drugs are suitable in combination).

Genomics

Comprehensive analyses of DNA, RNA, and epigenomes by using next-generation sequencing (NGS), microarray, and other technologies are used for such tasks as biomarker discovery, research into mechanisms of action, and new target discovery.

Proteomics

Comprehensive analyses of proteins by using mass spectrometry, chemical biology, and other cutting-edge technologies are used for such tasks as research into mechanisms of action, new target discovery, and biomarker discovery.

Informatics

Analyses of “Omics” data and analytical platform development by using machine learning (including artificial intelligence) are used for such tasks as biomarker discovery, research into mechanisms of action, and new target discovery.

Gene analysis

Microfluidic PCR technology, digital barcode technology, and in situ hybridization are used to analyze gene expression and mutations.

Protein analysis

Western blot and flow cytometry are used to analyze biomarkers. Multiplex technologies for cytokine measurement, blood biochemistry, and kinase panel profiling are used to evaluate the efficacy and mechanism of action of candidate drugs.

Molecular pathology

Technologies for pathological specimen preparation, laser microdissection, immunohistochemical staining, FISH, and electron microscopy are used for pathological evaluation, biomarker analysis, and target cancer identification.

Cell line panels

Cancer cell-line panels with various Omics data are used for biomarker discovery, mechanism of action analysis, target cancer identification, and establishment of drug-resistant cell lines.